Feasey, N. A., Dougan, G., Kingsley, R. A., Heyderman, R. S. & Gordon, M. A. Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa. Lancet 379, 2489–2499 (2012).
Google Scholar
Berkley, J. A. et al. Bacteremia among children admitted to a rural hospital in Kenya. N. Engl. J. Med. 352, 39–47 (2005).
Google Scholar
Enwere, G. et al. Epidemiologic and clinical characteristics of community-acquired invasive bacterial infections in children aged 2−29 months in The Gambia. Pediatr. Infect. Dis. J. 25, 700–705 (2006).
Google Scholar
Sigauque, B. et al. Community-acquired bacteremia among children admitted to a rural hospital in Mozambique. Pediatr. Infect. Dis. J. 28, 108–113 (2009).
Google Scholar
Tapia, M. D. et al. Invasive nontyphoidal Salmonella infections among children in Mali, 2002−2014: microbiological and epidemiologic features guide vaccine development. Clin. Infect. Dis. 61, S332–S338 (2015).
Google Scholar
GBD 2017 Non-Typhoidal Salmonella Invasive Disease Collaborators The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect. Dis. 19, 1312–1324 (2019).
Sow, S. O. et al. Haemophilus influenzae type B conjugate vaccine introduction in Mali: impact on disease burden and serologic correlate of protection. Am. J. Trop. Med. Hyg. 80, 1033–1038 (2009).
Google Scholar
GBD 2017 Typhoid and Paratyphoid Collaborators The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect. Dis. 19, 369–381 (2019).
Neuzil, K. M., Pollard, A. J. & Marfin, A. A. Introduction of typhoid conjugate vaccines in Africa and Asia. Clin. Infect. Dis. 68, S27–S30 (2019).
Google Scholar
Baliban, S. M. et al. Development of a glycoconjugate vaccine to prevent invasive Salmonella Typhimurium infections in sub-Saharan Africa. PLoS Negl. Trop. Dis. 11, e0005493 (2017).
Google Scholar
Simon, R. et al. Salmonella enterica serovar Enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. Enteritidis. Infect. Immun. 79, 4240–4249 (2011).
Google Scholar
Baliban, S. M. et al. Immunogenicity and induction of functional antibodies in rabbits immunized with a trivalent typhoid-invasive nontyphoidal Salmonella glycoconjugate formulation. Molecules 23, 1749 (2018).
Google Scholar
Burki, T. Typhoid conjugate vaccine gets WHO prequalification. Lancet Infect. Dis. 18, 258 (2018).
Google Scholar
Soble, A., Patel, Z., Sosler, S., Hampton, L. & Johnson, H. Gavi support for typhoid conjugate vaccines: moving from global investments to country introduction. Clin. Infect. Dis. 71, S160–S164 (2020).
Google Scholar
Simon, R. et al. A scalable method for biochemical purification of Salmonella flagellin. Protein Expr. Purif. 102, 1–7 (2014).
Google Scholar
Baliban, S. M. et al. Immunogenicity and efficacy following sequential parenterally-administered doses of Salmonella Enteritidis COPS:FliC glycoconjugates in infant and adult mice. PLoS Negl. Trop. Dis. 12, e0006522 (2018).
Google Scholar
Tennant, S. M. et al. Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infect. Immun. 79, 4175–4185 (2011).
Google Scholar
Muller-Loennies, S., Brade, L. & Brade, H. Neutralizing and cross-reactive antibodies against enterobacterial lipopolysaccharide. Int. J. Med. Microbiol. 297, 321–340 (2007).
Google Scholar
Nnalue, N. A., Khan, G. N. & Mustafa, N. Cross-reactivity between six Enterobacteriaceae complete lipopolysaccharide core chemotypes. J. Med. Microbiol. 48, 433–441 (1999).
Google Scholar
Balasubramanian, R. et al. The global burden and epidemiology of invasive non-typhoidal Salmonella infections. Hum. Vaccin. Immunother. 15, 1421–1426 (2019).
Google Scholar
Gordon, M. A. Invasive nontyphoidal Salmonella disease: epidemiology, pathogenesis and diagnosis. Curr. Opin. Infect. Dis. 24, 484–489 (2011).
Google Scholar
Bornstein, K. et al. Genetic changes associated with the temporal shift in invasive non-typhoidal Salmonella serovars in Bamako Mali. PLoS Negl. Trop. Dis. 13, e0007297 (2019).
Google Scholar
Kingsley, R. A. et al. Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res. 19, 2279–2287 (2009).
Google Scholar
Post, A. S. et al. Supporting evidence for a human reservoir of invasive non-typhoidal Salmonella from household samples in Burkina Faso. PLoS Negl. Trop. Dis. 13, e0007782 (2019).
Google Scholar
MacLennan, C. A. & Tennant, S. M. Comparing the roles of antibodies to nontyphoidal Salmonella enterica in high- and low-income countries and implications for vaccine development. Clin. Vaccine Immunol. 20, 1487–1490 (2013).
Google Scholar
Elias, S. C. et al. Complementary measurement of nontyphoidal Salmonella-specific IgG and IgA antibodies in oral fluid and serum. Heliyon 9, e12071 (2023).
Google Scholar
Smith, C. et al. Protocol for the challenge non-typhoidal Salmonella (CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection model in the UK. BMJ Open 14, e076477 (2024).
Google Scholar
Taylor, D. N. et al. Development of VAX128, a recombinant hemagglutinin (HA) influenza−flagellin fusion vaccine with improved safety and immune response. Vaccine 30, 5761–5769 (2012).
Google Scholar
Treanor, J. J. et al. Safety and immunogenicity of a recombinant hemagglutinin influenza−flagellin fusion vaccine (VAX125) in healthy young adults. Vaccine 28, 8268–8274 (2010).
Google Scholar
Turley, C. B. et al. Safety and immunogenicity of a recombinant M2e−flagellin influenza vaccine (STF2.4xM2e) in healthy adults. Vaccine 29, 5145–5152 (2011).
Google Scholar
Ramachandran, G. et al. Functional activity of antibodies directed towards flagellin proteins of non-typhoidal Salmonella. PLoS ONE 11, e0151875 (2016).
Google Scholar
Jin, C. et al. Vi-specific serological correlates of protection for typhoid fever. J. Exp. Med. 218, e20201116 (2021).
Google Scholar
Mora, J. R. & von Andrian, U. H. Differentiation and homing of IgA-secreting cells. Mucosal Immunol. 1, 96–109 (2008).
Google Scholar
Toapanta, F. R. et al. Gut-homing conventional plasmablasts and CD27− plasmablasts elicited after a short time of exposure to an oral live-attenuated Shigella vaccine candidate in humans. Front. Immunol. 5, 374 (2014).
Google Scholar
Wagner, N. et al. Critical role for β7 integrins in formation of the gut-associated lymphoid tissue. Nature 382, 366–370 (1996).
Google Scholar
Fiorino, F. et al. Immunogenicity of a bivalent adjuvanted glycoconjugate vaccine against Salmonella Typhimurium and Salmonella Enteritidis. Front. Immunol. 8, 168 (2017).
Google Scholar
Micoli, F. et al. Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella. Proc. Natl Acad. Sci. USA 115, 10428–10433 (2018).
Google Scholar
An, S. J. et al. Development of invasive non-typhoidal Salmonella conjugate vaccines and their evaluation in a trivalent formulation with typhoid conjugate vaccine. Vaccine 52, 126913 (2025).
Google Scholar
Boerth, E. M. et al. Induction of broad immunity against invasive Salmonella disease by a quadrivalent combination Salmonella MAPS vaccine targeting Salmonella enterica serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A. Vaccines 11, 1671 (2023).
Google Scholar
Kantele, A. Antibody-secreting cells in the evaluation of the immunogenicity of an oral vaccine. Vaccine 8, 321–326 (1990).
Google Scholar
Wahid, R., Kotloff, K. L., Levine, M. M. & Sztein, M. B. Cell mediated immune responses elicited in volunteers following immunization with candidate live oral Salmonella enterica serovar Paratyphi A attenuated vaccine strain CVD 1902. Clin. Immunol. 201, 61–69 (2019).
Google Scholar
Wahid, R. et al. Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+IgD− S. Typhi-specific IgA and IgG B memory cells in humans. Clin. Immunol. 138, 187–200 (2011).
Google Scholar
Wahid, R., Simon, R., Zafar, S. J., Levine, M. M. & Sztein, M. B. Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans. Clin. Vaccine Immunol. 19, 825–834 (2012).
Google Scholar
Simon, J. K. et al. Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates. Clin. Immunol. 139, 185–192 (2011).
Google Scholar
Simon, J. K. et al. Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates. Vaccine 27, 565–572 (2009).
Google Scholar
Wahid, R. et al. Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a. Clin. Immunol. 148, 35–43 (2013).
Google Scholar
Bernshtein, B. et al. Systems approach to define humoral correlates of immunity to Shigella. Cell Rep. 40, 111216 (2022).
Google Scholar
Brown, E. P. et al. Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. J. Immunol. Methods 455, 24–33 (2018).
Google Scholar
Karsten, C. B. et al. A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis. J. Immunol. Methods 471, 46–56 (2019).
Google Scholar
Ackerman, M. E. et al. A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J. Immunol. Methods 366, 8–19 (2011).
Google Scholar